Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832104 | 0.87 | CHRM2 (0.40) | CHRM2CHRM1CHRM3CHRM4NR1H2 | |
| SCHEMBL2652613 | 0.77 | CHRM2 (0.41) | CHRM2CHRM1CHRM3CHRM4KMT2A | |
| SCHEMBL9832437 | 0.76 | CHRM2 (0.40) | CHRM2CHRM1CHRM3CHRM4KMT2A | |
| SCHEMBL9832449 | 0.72 | CHRM2 (0.38) | CHRM2CHRM1CHRM3CHRM4KMT2A | |
| SCHEMBL7374418 | 0.72 | NPSR1 (0.41) | CHRM2CHRM1CHRM3CHRM4POLB | |
| SCHEMBL2654268 | 0.72 | ALDH1A1 (0.41) | CHRM2CHRM1CHRM3CHRM4POLB | |
| SCHEMBL826276 | 0.72 | CHRM3 (0.49) | CHRM2CHRM1CHRM3CHRM4POLB | |
| SCHEMBL4636677 | 0.72 | CHRM3 (0.48) | CHRM2CHRM1CHRM3CHRM4POLB | |
| SCHEMBL1234112 | 0.70 | CHRM2 (0.43) | CHRM2CHRM1CHRM3CHRM4L3MBTL1 | |
| SCHEMBL11468485 | 0.70 | RAB9A (0.41) | CHRM2CHRM1CHRM3CHRM4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |