Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831654 | 0.90 | MAPT (0.41) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9830311 | 0.89 | CYP1A2 (0.40) | CYP3A4MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9799289 | 0.86 | OPRM1 (0.43) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9799232 | 0.82 | OPRM1 (0.40) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Fedotozine SCHEMBL6418832 | 0.81 | OPRM1 (0.63) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Fedotozine SCHEMBL1649900 | 0.81 | OPRM1 (0.63) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Fedotozine SCHEMBL154629 | 0.81 | OPRM1 (0.63) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9832151 | 0.81 | OPRM1 (0.46) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9832805 | 0.79 | OPRM1 (0.70) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9831908 | 0.78 | CYP1A2 (0.42) | OPRM1OPRD1NR1I2CHRM2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |