Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.70 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9832430 | 0.94 | ALDH1A1 (0.74) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Fumaric Acid SCHEMBL9832433 | 0.94 | ALDH1A1 (0.74) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9834283 | 0.92 | OPRM1 (0.58) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9834251 | 0.91 | OPRM1 (0.60) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9833668 | 0.85 | OPRM1 (0.57) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9831458 | 0.83 | SLC6A3 (0.51) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Trimebutine SCHEMBL25705 | 0.82 | OPRM1 (1.00) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Trimebutine SCHEMBL14273976 | 0.82 | OPRM1 (1.00) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| SCHEMBL9831888 | 0.82 | OPRM1 (0.74) | OPRM1OPRD1NR1I2CHRM2ADORA3 | |
| Trimebutine SCHEMBL7428847 | 0.81 | OPRM1 (0.98) | OPRM1OPRD1NR1I2CHRM2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333315-B1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | Dr. Lo. Zambeletti S.p.A. (IT) | 1991-06-12 | — | — | EP | disclosed |
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4994450-A | Side effect reduction | DR. LO. ZAMBELETTI S.P.A. (IT) | 1991-02-19 | — | — | US | disclosed |
| EP-0333315-A1 | Azacyclic compounds, processes for their preparation and their pharmaceutical use | Dr. Lo. Zambeletti S.p.A. (IT) | 1989-09-20 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |