Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111901 | 0.85 | TP53 (0.42) | RAB9AL3MBTL1KMT2ATP53PTGS1 | |
| SCHEMBL9522928 | 0.85 | TP53 (0.42) | RAB9AL3MBTL1KMT2ATP53PTGS1 | |
| SCHEMBL9832793 | 0.85 | TP53 (0.46) | RAB9AL3MBTL1KMT2ATP53CCNA2 | |
| SCHEMBL9316737 | 0.83 | TP53 (0.49) | RAB9AL3MBTL1KMT2ATP53MEN1 | |
| SCHEMBL9832040 | 0.83 | TP53 (0.43) | RAB9AL3MBTL1KMT2ATP53PTGS1 | |
| SCHEMBL9833868 | 0.83 | P2RX7 (0.38) | KMT2AAURKACCNA2CDK2CCNA1 | |
| SCHEMBL8113736 | 0.83 | TP53 (0.45) | RAB9AL3MBTL1KMT2ATP53CCNA2 | |
| SCHEMBL9339764 | 0.83 | TP53 (0.45) | RAB9AL3MBTL1KMT2ATP53CCNA2 | |
| SCHEMBL9831159 | 0.82 | TP53 (0.40) | RAB9AL3MBTL1KMT2ATP53PTGS1 | |
| SCHEMBL9834310 | 0.82 | TP53 (0.46) | RAB9AL3MBTL1KMT2ATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| US-4816467-A | BACTERICIDES, VIRICIDES | FARMITALIA CARLO ERBA S.R.L (IT) | 1989-03-28 | — | — | US | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |