Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | S100B | P04271 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831848 | 0.75 | HTR1A (0.47) | ALDH1A1MAPTMEN1KMT2AIP6K1 | |
| SCHEMBL20424766 | 0.72 | MAPT (0.43) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL21598636 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL22864685 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1KMT2AIP6K1 | |
| SCHEMBL30451639 | 0.72 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL24252459 | 0.72 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL22864690 | 0.72 | MAPT (0.53) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4499783 | 0.70 | ALDH1A1 (0.60) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL9830989 | 0.70 | IP6K1 (0.33) | ALDH1A1MAPTMEN1KMT2AIP6K1 | |
| SCHEMBL5951340 | 0.70 | ALDH1A1 (0.47) | ALDH1A1MAPTMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |