Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.30 |
| ▸ | POLB | P06746 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 3/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829972 | 0.66 | DRD2 (0.36) | HRH3MEN1POLBMAPTKMT2A | |
| SCHEMBL19851303 | 0.61 | — | — | |
| SCHEMBL12262527 | 0.56 | HRH3 (0.30) | HRH3 | |
| SCHEMBL304915 | 0.54 | SLC18A3 (0.56) | MEN1POLBKMT2AALDH1A1LMNA | |
| SCHEMBL9145349 | 0.53 | — | — | |
| SCHEMBL10562689 | 0.52 | SLC18A3 (0.50) | POLBMAPTKMT2AALDH1A1 | |
| SCHEMBL22142098 | 0.52 | CHRNA7 (0.36) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1473027 | 0.52 | ALDH1A1 (0.36) | HRH3MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL38665299 | 0.51 | SLC18A3 (0.49) | POLBMAPTKMT2AALDH1A1 | |
| SCHEMBL5508352 | 0.51 | ALDH1A1 (0.60) | HRH3MAPTALDH1A1LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |