Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829970 | 0.68 | ALDH1A1 (0.35) | DRD2DRD3MEN1USP2LMNA | |
| SCHEMBL9832753 | 0.67 | DRD2 (0.34) | DRD2DRD3 | |
| SCHEMBL10408223 | 0.67 | ALDH1A1 (0.37) | DRD2DRD3MEN1USP2LMNA | |
| SCHEMBL9832760 | 0.66 | HRH3 (0.34) | MEN1USP2LMNAPOLBMAPT | |
| SCHEMBL10791099 | 0.66 | ALDH1A1 (0.37) | DRD2DRD3LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL24595155 | 0.64 | DRD2 (0.39) | DRD2DRD3LMNAMAPTALDH1A1 | |
| SCHEMBL20990812 | 0.62 | DRD2 (0.52) | DRD2DRD3MEN1KMT2AALDH1A1 | |
| SCHEMBL5508352 | 0.61 | ALDH1A1 (0.60) | DRD2DRD3LMNAMAPTRECQL | |
| SCHEMBL152019 | 0.61 | DRD3 (0.41) | DRD3HTR1DL3MBTL3L3MBTL1PDCD1 | |
| SCHEMBL2786474 | 0.61 | ALDH1A1 (0.46) | DRD2DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |