Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9266966 | 0.80 | DNMT3B (0.47) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL10534400 | 0.73 | NR4A1 (0.42) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL469131 | 0.71 | CUL4A (0.43) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL10407685 | 0.70 | KMT2A (0.39) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL30335476 | 0.70 | NR4A1 (0.44) | ALDH1A1KMT2AMEN1TDP1MAPT | |
| SCHEMBL11615897 | 0.70 | TDP1 (0.42) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL7711681 | 0.70 | CUL4A (0.48) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL19366233 | 0.68 | HSD17B10 (0.43) | ALDH1A1TSHRHSD17B10CASP7KMT2A | |
| SCHEMBL10407683 | 0.68 | KMT2A (0.48) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL9100356 | 0.67 | TDP1 (0.43) | ALDH1A1HSD17B10CASP7KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362695-B1 | PYRROLOCARBAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | disclosed |
| EP-0362695-A1 | Pyrrolocarbazole derivatives, processes for their preparation and their use as medicaments | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-04-11 | — | — | EP | disclosed |
| US-4912107-A | Pyrrolocarbazole derivatives, compositions containing them, and methods for using them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |