Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833486 | 0.90 | TDP2 (0.45) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9830572 | 0.89 | ALDH1A1 (0.42) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9831088 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL10372619 | 0.86 | TNKS2 (0.46) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9834567 | 0.83 | ALDH1A1 (0.35) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9833956 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL10373863 | 0.77 | TNKS2 (0.46) | KDM4EALDH1A1KMT2AGAATSHR | |
| SCHEMBL9833587 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9833862 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1HSD17B10KMT2ATSHR | |
| SCHEMBL9832940 | 0.74 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |