Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833545 | 0.82 | ALOX5 (0.46) | ALOX5POLBALDH1A1MEN1KMT2A | |
| SCHEMBL9832426 | 0.73 | ALOX5 (0.71) | ALOX5POLBALDH1A1MEN1KMT2A | |
| SCHEMBL9764824 | 0.72 | NPC1 (0.43) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8805996 | 0.70 | ALOX5 (0.54) | ALOX5ALDH1A1KMT2AGLAKDM4E | |
| SCHEMBL11800602 | 0.70 | MAPT (0.51) | ALOX5POLBALDH1A1MEN1KMT2A | |
| SCHEMBL8824436 | 0.68 | ALDH1A1 (0.57) | POLBALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL22110976 | 0.68 | MAPT (0.50) | ALOX5POLBALDH1A1MEN1KMT2A | |
| Tetrabuthylammonium SCHEMBL9833807 | 0.68 | ALOX5 (0.55) | ALOX5POLBALDH1A1MEN1KMT2A | |
| SCHEMBL8806385 | 0.67 | PKM (0.53) | ALOX5POLBALDH1A1MEN1KMT2A | |
| SCHEMBL23735958 | 0.67 | MAPT (0.46) | ALOX5POLBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388429-A4 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0388429-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| WO-1989004299-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-05-18 | — | — | WO | disclosed |