Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835326 | 0.91 | LMNA (0.54) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL2432475 | 0.79 | LMNA (0.72) | LMNAPOLBCETPALDH1A1KMT2A | |
| SCHEMBL10072798 | 0.78 | CETP (0.54) | LMNAPOLBCETPALDH1A1MEN1 | |
| SCHEMBL15621420 | 0.77 | PDK1 (0.69) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL16998375 | 0.77 | TRPV1 (0.52) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL3535796 | 0.76 | PDK1 (0.68) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL29524443 | 0.76 | PDK1 (0.68) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL3793230 | 0.75 | PDK1 (0.55) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL3785961 | 0.74 | CETP (0.58) | LMNAPOLBPDK1PDK2PDK3 | |
| SCHEMBL11910714 | 0.74 | TAAR1 (0.54) | LMNAPOLBMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205272-B1 | CINNOLINE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4886800-A | Substituted cinnoline derivatives as CNS depressants | ICI AMERICAS INC. (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0205272-A2 | Cinnoline derivatives | ICI AMERICAS INC. (US) | 1986-12-17 | — | — | EP | disclosed |