Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831088 | 0.89 | KDM4E (0.41) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL9830572 | 0.85 | ALDH1A1 (0.42) | KDM4EMAPTMEN1KMT2ARECQL | |
| SCHEMBL9833956 | 0.85 | KDM4E (0.52) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL9831225 | 0.80 | KDM4E (0.44) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL9831252 | 0.80 | KDM4E (0.46) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL9831454 | 0.78 | MAPT (0.42) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL9831375 | 0.77 | KDM4E (0.41) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL10373863 | 0.76 | TNKS2 (0.46) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL10473665 | 0.76 | MAPT (0.42) | KDM4EMAPTMEN1MAPK1KMT2A | |
| SCHEMBL9832287 | 0.75 | KDM4E (0.41) | KDM4EMAPTMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |