Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HK1 | P19367 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.36 |
| ▸ | CDK1 | P06493 | 4/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29622074 | 0.76 | CCNB2 (0.54) | KDM4EMAPTMAPK1BLMHTR5A | |
| SCHEMBL12169756 | 0.76 | HTR5A (0.46) | MEN1KMT2AHTR5ACDK5CDK5R1 | |
| SCHEMBL152281 | 0.76 | CCNB2 (0.54) | KDM4EMAPTMAPK1BLMHTR5A | |
| SCHEMBL5141694 | 0.74 | NPC1 (0.47) | MEN1KMT2AKDM4ENPC1HSP90AA1 | |
| SCHEMBL20777511 | 0.74 | HTR5A (0.52) | HTR5ACDK5CDK5R1ALDH1A1CREBBP | |
| SCHEMBL25463173 | 0.67 | HTR5A (0.42) | MAPTHTR5ACDK5CDK5R1CCNB2 | |
| SCHEMBL5137969 | 0.67 | CASP3 (0.53) | MEN1KMT2ACDK5CDK5R1CCNB2 | |
| SCHEMBL29754448 | 0.67 | NPC1 (0.50) | NPC1MAPTHTR5ACDK5CDK5R1 | |
| SCHEMBL1764170 | 0.67 | NPC1 (0.50) | NPC1MAPTHTR5ACDK5CDK5R1 | |
| SCHEMBL29453856 | 0.66 | KMT2A (1.00) | MEN1KMT2AKDM4ENPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |