Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 2/20 | 0.53 |
| ▸ | TDP2 | O95551 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | CASP9 | P55211 | 1/20 | 0.53 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852644 | 0.81 | CASP7 (0.53) | CASP3CASP6TDP2CASP7CASP9 | |
| SCHEMBL5141694 | 0.80 | NPC1 (0.47) | CDK5CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL2087698 | 0.78 | TDP2 (0.66) | CASP3CASP6TDP2CASP7CASP9 | |
| SCHEMBL14084317 | 0.75 | TDP2 (0.61) | CASP3CASP6TDP2CASP7CASP9 | |
| SCHEMBL10694265 | 0.75 | MAOA (0.61) | CASP3CASP6PARP1PARP10PARP11 | |
| SCHEMBL29622074 | 0.74 | CCNB2 (0.54) | CDK5CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL152281 | 0.74 | CCNB2 (0.54) | CDK5CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL135721 | 0.74 | PNMT (0.53) | CASP3CASP6PARP1PARP10PARP11 | |
| SCHEMBL27878508 | 0.74 | PNMT (0.53) | CASP3CASP6PARP1PARP10PARP11 | |
| SCHEMBL12834903 | 0.74 | AHR (0.53) | TDP2POLBLRRK2PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924580-A1 | NON-STEROIDAL COMPOUNDS USEFUL AS GLUCOCORTICOID RECEPTOR MODULATORS | N.V. Organon (NL) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025938-A1 | NON-STEROIDAL COMPOUNDS USEFUL AS GLUCOCORTICOID RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2007-03-08 | — | — | WO | disclosed |