Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 15/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832475 | 0.81 | BRD4 (0.32) | — | |
| SCHEMBL9832939 | 0.80 | ALDH1A1 (0.43) | PGRHTR7HTR1ADRD2DRD1 | |
| SCHEMBL10373501 | 0.79 | PGR (0.44) | PGRLMNAHTR7 | |
| SCHEMBL9834972 | 0.77 | ATAD2 (0.50) | PGR | |
| SCHEMBL9833527 | 0.76 | ALDH1A1 (0.49) | PGRLMNAHTR7ALDH1A1 | |
| SCHEMBL10568514 | 0.76 | ALDH1A1 (0.45) | PGRHTR7ALDH1A1 | |
| SCHEMBL9832258 | 0.74 | PGR (0.47) | PGRLMNAHTR7HTR1ADRD2 | |
| SCHEMBL10472875 | 0.73 | PGR (0.37) | PGRHTR7HTR1ADRD2DRD1 | |
| SCHEMBL9832126 | 0.73 | KDM4E (0.47) | PGRALDH1A1 | |
| SCHEMBL5561847 | 0.72 | PGR (0.46) | PGRLMNAHTR7HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |