Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833080 | 0.96 | MAPT (0.44) | MAPTCNR1POLBPTGS1PTGS2 | |
| SCHEMBL9319611 | 0.93 | MAPT (0.43) | MAPTCNR1POLBPTGS1PTGS2 | |
| SCHEMBL9832762 | 0.93 | MAPT (0.41) | MAPTPOLBPTGS1PTGS2IKBKB | |
| SCHEMBL9834264 | 0.92 | MAPT (0.41) | MAPTCNR1POLBIKBKBTP53 | |
| SCHEMBL9833393 | 0.92 | ALDH1A1 (0.40) | MAPTCNR1POLBIKBKBALDH1A1 | |
| SCHEMBL9831820 | 0.91 | MAPT (0.43) | MAPTPOLBPTGS1PTGS2IKBKB | |
| SCHEMBL9832537 | 0.91 | LMNA (0.42) | MAPTCNR1POLBIKBKBTP53 | |
| SCHEMBL9316748 | 0.88 | MAPT (0.44) | MAPTPOLBPTGS1PTGS2TP53 | |
| SCHEMBL9834065 | 0.87 | RIPK1 (0.39) | MAPTPOLBPTGS1PTGS2TP53 | |
| SCHEMBL9831070 | 0.87 | NR1H4 (0.41) | MAPTPOLBCYP1A2HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| US-4816467-A | BACTERICIDES, VIRICIDES | FARMITALIA CARLO ERBA S.R.L (IT) | 1989-03-28 | — | — | US | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |