Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835029 | 0.85 | MAOB (0.39) | MAOBMAPTTP53LMNATHRB | |
| SCHEMBL9834389 | 0.78 | PGR (0.41) | — | |
| SCHEMBL10375402 | 0.78 | TNKS2 (0.42) | MAOBMAPTTP53LMNATHRB | |
| SCHEMBL10566724 | 0.76 | MAOB (0.34) | MAOBMAPTTP53LMNATHRB | |
| SCHEMBL9834604 | 0.75 | PGR (0.46) | MAPTTP53LMNAIDO1 | |
| SCHEMBL9833533 | 0.75 | MAOB (0.40) | MAOBMAPTTP53LMNATHRB | |
| SCHEMBL10376075 | 0.74 | TNKS2 (0.47) | MAOBMAPTTP53LMNATHRB | |
| Hydrochloric Acid SCHEMBL10376017 | 0.73 | MAOB (0.40) | MAOBMAPTTP53LMNATHRB | |
| SCHEMBL10376369 | 0.73 | MAOB (0.39) | MAOBMAPTTP53LMNATHRB | |
| SCHEMBL9834705 | 0.73 | NQO2 (0.39) | MAPTTP53LMNAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |