Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835287 | 0.88 | NR3C1 (0.67) | PDE4BNR3C1PGR | |
| SCHEMBL10759905 | 0.87 | PDE4B (0.56) | PDE4BNR3C1PDE5AALDH1A1SMN1; SMN2 | |
| SCHEMBL9834161 | 0.87 | PDE4B (0.60) | PDE4BNR3C1PGRPDE5AMAPT | |
| SCHEMBL9833323 | 0.87 | NR3C1 (0.53) | PDE4BNR3C1PGRPDE5AALDH1A1 | |
| SCHEMBL9836172 | 0.86 | NR3C1 (0.55) | PDE4BNR3C1PGRPDE5A | |
| SCHEMBL9835965 | 0.86 | NR3C1 (0.60) | PDE4BNR3C1PGRPDE5A | |
| SCHEMBL5260422 | 0.85 | LMNA (0.50) | NR3C1ALDH1A1SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL9834731 | 0.83 | NR3C1 (0.55) | PDE4BNR3C1PGRALDH1A1MAPT | |
| SCHEMBL4346173 | 0.82 | NR3C1 (0.81) | PDE4BNR3C1PGRPDE5A | |
| SCHEMBL9836690 | 0.81 | NR3C1 (0.55) | PDE4BNR3C1PGRPDE5APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230016-B1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |