Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | RORC | P51449 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 3/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92487 | 0.86 | ELOVL1 (0.65) | ELOVL1PRKACAROCK1KMT2AMEN1 | |
| SCHEMBL9153870 | 0.80 | MAPK1 (0.55) | KMT2AMEN1LMNATP53SMN1; SMN2 | |
| SCHEMBL28268613 | 0.80 | RAB9A (0.75) | ELOVL1PRKACAROCK1KMT2AMEN1 | |
| SCHEMBL2664517 | 0.80 | KDM4E (0.69) | KMT2AMEN1LMNASMN1; SMN2PDE5A | |
| SCHEMBL19380614 | 0.79 | ELOVL1 (1.00) | ELOVL1PRKACAROCK1KMT2AMEN1 | |
| SCHEMBL353851 | 0.79 | SMN1; SMN2 (0.73) | KMT2AMEN1LMNATP53SMN1; SMN2 | |
| SCHEMBL9677782 | 0.78 | SMN1; SMN2 (0.71) | KMT2AMEN1LMNASMN1; SMN2PDE5A | |
| SCHEMBL10084285 | 0.77 | ELOVL1 (0.64) | ELOVL1PRKACAROCK1KMT2AMEN1 | |
| SCHEMBL77834 | 0.77 | KMT2A (0.77) | ELOVL1PRKACAROCK1KMT2AMEN1 | |
| SCHEMBL13357604 | 0.76 | ROCK1 (1.00) | ELOVL1PRKACAROCK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |