Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477103 | 0.84 | ADRB2 (0.36) | SMN1; SMN2ALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL7619339 | 0.75 | MAPK1 (0.37) | ALDH1A1NPC1MAPTTSHRRAB9A | |
| SCHEMBL8073977 | 0.75 | CTSS (0.46) | PPIACTSSCTSLCTSBSMN1; SMN2 | |
| SCHEMBL14743991 | 0.72 | CTSL (0.52) | CTSSCTSLCTSBSMN1; SMN2ATM | |
| SCHEMBL8085796 | 0.71 | PPIA (0.49) | PPIACTSSCTSLCTSBCTSK | |
| SCHEMBL2704426 | 0.71 | CTSS (0.52) | CTSSCTSLCTSBSMN1; SMN2ATM | |
| SCHEMBL14743992 | 0.71 | CTSL (0.54) | CTSSCTSLCTSBSMN1; SMN2ALDH1A1 | |
| SCHEMBL143763 | 0.71 | CTSS (0.57) | CTSSCTSLCTSBSMN1; SMN2ATM | |
| SCHEMBL584447 | 0.70 | MEN1 (0.47) | CTSSCTSLCTSBSMN1; SMN2ATM | |
| SCHEMBL26833122 | 0.70 | DDB1 (0.44) | CTSSCTSLCTSBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299963-B1 | RENIN INHIBITORS HAVING A LACTAM PSEUDO DIPEPTIDE | THE UPJOHN COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4705846-A | Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert | THE UPJOHN COMPANY (US) | 1987-11-10 | — | — | US | disclosed |