Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.44 |
| ▸ | CMA1 | P23946 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31010750 | 0.82 | AHR (0.59) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL9833717 | 0.76 | PDE3B (0.54) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| Hydrochloric Acid SCHEMBL10470469 | 0.75 | PDE3B (0.52) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL9762771 | 0.75 | AHR (0.48) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL10566220 | 0.73 | ALDH1A1 (0.50) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL1436084 | 0.72 | GRIA1 (0.53) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL9298074 | 0.68 | AHR (0.50) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL5441646 | 0.68 | AHR (0.60) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL548762 | 0.68 | AHR (0.50) | AHRCMA1PDE3BPDE3AEIF2AK2 | |
| SCHEMBL4065845 | 0.68 | AHR (0.60) | AHRCMA1PDE3BPDE3AEIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |