Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 4/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10470469 | 0.99 | PDE3B (0.52) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9832094 | 0.83 | CYP11B1 (0.53) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL9834566 | 0.76 | AHR (0.44) | PDE3BPDE3AEPHX2AHRCMA1 | |
| SCHEMBL10566220 | 0.73 | ALDH1A1 (0.50) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL31010750 | 0.73 | AHR (0.59) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL9832061 | 0.71 | PDE3B (0.49) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL23143482 | 0.70 | PDE3B (1.00) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL6744175 | 0.70 | PDE3B (0.76) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL29850050 | 0.70 | PDE3B (0.76) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL9762771 | 0.70 | AHR (0.48) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |