Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.38 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117209 | 0.74 | HTR3A (0.41) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL11128579 | 0.74 | CHRM3 (0.42) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL11109479 | 0.74 | CHRNA7 (0.41) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL11115203 | 0.73 | CHRM2 (0.39) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL11113361 | 0.72 | CHRNA7 (0.44) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL11113541 | 0.72 | CHRM2 (0.38) | CHRM2CHRM1CHRM3CHRNA7GAA | |
| SCHEMBL11116121 | 0.72 | CHRM3 (0.38) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL11115518 | 0.71 | CHRM2 (0.36) | CHRM2CHRM1CHRM3CHRNA7GAA | |
| SCHEMBL11115200 | 0.71 | CHRNA7 (0.38) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL9835161 | 0.70 | HRH3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129879-B1 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |
| US-4547496-A | Antiulcer [1] benzepino[3,4-b]pyridine and compositions | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-10-15 | — | — | US | disclosed |
| EP-0129879-A2 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-02 | — | — | EP | disclosed |