Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836609 | 0.91 | MEN1 (0.41) | — | |
| SCHEMBL9836629 | 0.79 | CYP2C19 (0.41) | TSHRDRD2KCNH2ADRA2CADRA2A | |
| SCHEMBL9835877 | 0.79 | GRIN1 (0.42) | LTA4H | |
| SCHEMBL9834971 | 0.77 | ALDH1A1 (0.36) | ALOX15DRD2LTA4H | |
| SCHEMBL9834568 | 0.76 | HSP90AA1 (0.38) | ALOX15TSHRKCNH2 | |
| SCHEMBL9835639 | 0.76 | ALDH1A1 (0.42) | ALOX15LTA4H | |
| SCHEMBL11117514 | 0.73 | TBXAS1 (0.38) | HRH3TSHRDPP7 | |
| SCHEMBL9836786 | 0.72 | DRD2 (0.43) | TSHRDRD2 | |
| SCHEMBL9836237 | 0.72 | ALDH1A1 (0.41) | — | |
| SCHEMBL9834804 | 0.70 | CHRM2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129879-B1 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-09-11 | — | — | EP | claimed |
| US-4547496-A | Antiulcer [1] benzepino[3,4-b]pyridine and compositions | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-10-15 | — | — | US | claimed |
| EP-0129879-A2 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-02 | — | — | EP | claimed |