Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836412 | 0.89 | ALDH1A1 (0.51) | ALDH1A1LMNAGAASMN1; SMN2PKM | |
| SCHEMBL10474223 | 0.87 | PDE3B (0.56) | ALDH1A1LMNAGAAKMT2ASMN1; SMN2 | |
| SCHEMBL9836932 | 0.86 | TSHR (0.43) | ALDH1A1LMNASMN1; SMN2PKMBCHE | |
| SCHEMBL10763649 | 0.84 | TP53 (0.40) | ALDH1A1LMNAGAAKMT2ASMN1; SMN2 | |
| SCHEMBL9835522 | 0.83 | HPGD (0.45) | ALDH1A1LMNAGAAKMT2ASMN1; SMN2 | |
| SCHEMBL10431228 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNAKMT2ASMN1; SMN2PKM | |
| SCHEMBL9835976 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1LMNASMN1; SMN2USP2 | |
| SCHEMBL9834628 | 0.81 | MAPT (0.43) | ALDH1A1LMNAGAASMN1; SMN2MAPT | |
| SCHEMBL9837594 | 0.81 | PDE3B (0.41) | ALDH1A1LMNAKMT2ASMN1; SMN2PKM | |
| SCHEMBL9835458 | 0.79 | PDE4A (0.40) | ALDH1A1LMNAKMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | claimed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | claimed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | claimed |
| JP-63119475-A | — | — | None | — | — | JP | disclosed |
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| JP-S63119475-A | 1,2,4-TRIAZINONE DERIVATIVE | SANKYO CO LTD | 1988-05-24 | — | — | JP | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |