Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | OGG1 | O15527 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836932 | 0.89 | TSHR (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9836476 | 0.87 | TDP1 (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9834628 | 0.86 | MAPT (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9836049 | 0.85 | MEN1 (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9835522 | 0.84 | HPGD (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9834522 | 0.83 | ALDH1A1 (0.42) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9836412 | 0.83 | ALDH1A1 (0.51) | SMN1; SMN2HPGDRAB9ATP53MAPT | |
| SCHEMBL9835976 | 0.83 | SMN1; SMN2 (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10431228 | 0.81 | ALDH1A1 (0.59) | SMN1; SMN2TSHRKMT2AHPGDNPC1 | |
| SCHEMBL9835111 | 0.81 | ALDH1A1 (0.53) | SMN1; SMN2KMT2ATP53MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |