Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836264 | 0.82 | PDE3B (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9836958 | 0.80 | PDE3B (0.37) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9835111 | 0.79 | ALDH1A1 (0.53) | MAPTALDH1A1KMT2ALMNATP53 | |
| SCHEMBL9835807 | 0.78 | KMO (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10763649 | 0.77 | TP53 (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9836532 | 0.76 | PDE3B (0.35) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9836476 | 0.72 | TDP1 (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10763656 | 0.71 | MTNR1A (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9837594 | 0.69 | PDE3B (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9837456 | 0.69 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | claimed |