Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5705156 | 0.78 | ALDH1A1 (0.44) | HTR1AHTR1DHTR1FALDH1A1HPGD | |
| SCHEMBL18324790 | 0.74 | HTR1A (0.49) | HTR1AHTR1DHTR1FALDH1A1MAPT | |
| SCHEMBL12813209 | 0.70 | CHRNB4 (0.49) | ALDH1A1MAPTGAARAB9AHIF1A | |
| SCHEMBL8113614 | 0.70 | GAPDH (0.52) | ALDH1A1MAPTHIF1A | |
| SCHEMBL2227387 | 0.69 | CHRNB4 (0.44) | ALDH1A1HPGDLMNAMAPTGAA | |
| SCHEMBL4184580 | 0.68 | ALDH1A1 (0.58) | ALDH1A1HPGDLMNAMAPTGAA | |
| SCHEMBL9836165 | 0.68 | KDM4E (0.63) | HTR1AHTR1DHTR1FALDH1A1MAPT | |
| SCHEMBL9942558 | 0.68 | CHRNB4 (0.49) | ALDH1A1MAPTRAB9A | |
| SCHEMBL27596768 | 0.68 | CHRNB4 (0.49) | ALDH1A1MAPTGAAKMT2ARAB9A | |
| SCHEMBL27634211 | 0.68 | CHRNB4 (0.49) | ALDH1A1MAPTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1017707-B | PROCESS FOR PREPARATION OF NEW THIAZOLE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-08-05 | — | — | CN | disclosed |
| EP-0224919-B1 | NEW THIAZOLE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4742057-A | Antiallergic thiazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-03 | — | — | US | disclosed |
| CN-86108205-A | New thiazolium compounds and preparation method thereof and their pharmaceutical composition | — | 1987-06-17 | — | — | CN | disclosed |
| EP-0224919-A2 | New thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-10 | — | — | EP | disclosed |