Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832398 | 0.90 | PSEN1 (0.50) | KDM4ESMN1; SMN2RECQLPSEN1PSEN2 | |
| SCHEMBL9835353 | 0.85 | SMN1; SMN2 (0.56) | KDM4ESMN1; SMN2RECQLPSEN1PSEN2 | |
| SCHEMBL9833732 | 0.85 | ALDH1A1 (0.68) | KDM4ESMN1; SMN2RECQLPSEN1PSEN2 | |
| SCHEMBL9835154 | 0.85 | SMN1; SMN2 (0.56) | KDM4ESMN1; SMN2RECQLPSEN1PSEN2 | |
| SCHEMBL7648169 | 0.81 | KDM4E (0.81) | KDM4ESMN1; SMN2RECQLMMP2MMP9 | |
| SCHEMBL4041413 | 0.81 | KDM4E (0.74) | KDM4ESMN1; SMN2RECQLMMP2MMP9 | |
| SCHEMBL1711883 | 0.80 | SMN1; SMN2 (0.56) | KDM4ESMN1; SMN2RECQLPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL7254237 | 0.80 | KDM4E (0.78) | KDM4ESMN1; SMN2RECQLMMP2MMP9 | |
| SCHEMBL812698 | 0.80 | SMN1; SMN2 (0.78) | KDM4ESMN1; SMN2RECQLALDH1A1HTT | |
| SCHEMBL8396710 | 0.80 | SMN1; SMN2 (0.78) | KDM4ESMN1; SMN2RECQLALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242518-B1 | Cycloalkano[1,2-b]indole-sulfonamides | BAYER AG (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4988820-A | Inhibiting platelet aggregation, anticoagulants, thromboxane a2 antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4965258-A | Anticoagulant; thromboxane a2 antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1990-10-23 | — | — | US | disclosed |
| US-4904797-A | REACTING A (BENZENESULFONAMIDOALKYL)CYCLOALKANO(1,2-B)INDOLE WITH ACRYLONITRILE; HYDROLYSIS, HYDROGENATION, REDUCTION | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-27 | — | — | US | disclosed |
| US-4827032-A | INTERMEDIATES FOR ANTICOAGULANTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-05-02 | — | — | US | disclosed |