Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PARG | Q86W56 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.50 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSC | P53634 | 2/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711630 | 0.90 | UCHL1 (0.54) | SMN1; SMN2KDM4ERECQLPARGUCHL1 | |
| SCHEMBL9832398 | 0.90 | PSEN1 (0.50) | SMN1; SMN2KDM4ERECQLPARGCTSB | |
| SCHEMBL8355420 | 0.87 | KDM4E (0.67) | SMN1; SMN2KDM4ERECQLPARGCTSB | |
| SCHEMBL2225334 | 0.87 | KDM4E (0.67) | SMN1; SMN2KDM4ERECQLPARGCTSB | |
| Hydrochloric Acid SCHEMBL15687975 | 0.85 | KDM4E (0.64) | SMN1; SMN2KDM4ERECQLPARGCTSB | |
| SCHEMBL7648169 | 0.83 | KDM4E (0.81) | SMN1; SMN2KDM4ERECQLMMP2MMP9 | |
| SCHEMBL4041413 | 0.83 | KDM4E (0.74) | SMN1; SMN2KDM4ERECQLCTSBCTSK | |
| SCHEMBL9594597 | 0.83 | KDM4E (0.58) | SMN1; SMN2KDM4ERECQLPARGUCHL1 | |
| SCHEMBL9832886 | 0.83 | ALDH1A1 (0.71) | SMN1; SMN2KDM4ERECQLPSEN1PSEN2 | |
| SCHEMBL9015380 | 0.83 | KDM4E (0.58) | SMN1; SMN2KDM4ERECQLHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191483-A1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016037591-A1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-03-17 | — | — | WO | disclosed |
| EP-2344449-A1 | ARYL-PHENYL-SULFONAMIDO-CYCLOALKYL COMPOUNDS AND THEIR USE | Pimco 2664 Limited (GB) | 2011-07-20 | — | — | EP | disclosed |
| EP-0242518-B1 | Cycloalkano[1,2-b]indole-sulfonamides | BAYER AG (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4988820-A | Inhibiting platelet aggregation, anticoagulants, thromboxane a2 antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4965258-A | Anticoagulant; thromboxane a2 antagonist | BAYER AKTIENGESELLSCHAFT (DE) | 1990-10-23 | — | — | US | disclosed |
| US-4904797-A | REACTING A (BENZENESULFONAMIDOALKYL)CYCLOALKANO(1,2-B)INDOLE WITH ACRYLONITRILE; HYDROLYSIS, HYDROGENATION, REDUCTION | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-27 | — | — | US | disclosed |
| US-4827032-A | INTERMEDIATES FOR ANTICOAGULANTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-05-02 | — | — | US | disclosed |
| EP-0242518-A1 | Cycloalkano[1,2-b]indole-sulfonamides | BAYER AG (DE) | 1987-10-28 | — | — | EP | disclosed |