Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 6/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL28786267 | 0.92 | PTK2 (0.36) | PTK2HTR4MELKROCK2SSTR1 | |
| Tert-Butyl Formate SCHEMBL27802920 | 0.92 | SSTR1 (0.36) | PTK2HTR4MELKROCK2SSTR1 | |
| SCHEMBL984646 | 0.91 | ACKR3 (0.41) | PTK2HTR4KDM1AALDH1A1KMT2A | |
| SCHEMBL984599 | 0.90 | BTK (0.39) | PBKMRGPRX1KDM1A | |
| SCHEMBL982008 | 0.90 | BTK (0.40) | PTK2MRGPRX1KMT2A | |
| Hydrochloric Acid SCHEMBL986113 | 0.90 | ACKR3 (0.41) | PTK2HTR4KDM1AALDH1A1KMT2A | |
| SCHEMBL983264 | 0.90 | BTK (0.40) | PTK2MRGPRX1MEN1ALDH1A1KMT2A | |
| SCHEMBL983586 | 0.90 | BTK (0.35) | MELKROCK2MRGPRX1MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL985798 | 0.89 | ACKR3 (0.38) | PTK2HTR4KDM1AALDH1A1KMT2A | |
| SCHEMBL981511 | 0.88 | KDM1A (0.42) | PTK2HTR4PBKKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | PTK2 4247/4885HTR4 1818/4885MELK 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.