SCHEMBL9835624

SCHEMBL9835624

O=C(O)c1cc2c(s1)CCC(CCn1ccnc1)C2

nearest known ligand 0.80

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 15/20 0.80
ALDH1A1 P00352 1/20 0.48
GAA P10253 1/20 0.48
NPC1 O15118 1/20 0.40
CYP19A1 P11511 1/20 0.39
DAO P14920 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9837178 0.90 TBXAS1 (0.65) TBXAS1ALDH1A1GAANPC1
SCHEMBL9836178 0.89 TBXAS1 (1.00) TBXAS1ALDH1A1GAANPC1DAO
SCHEMBL9835495 0.79 TBXAS1 (0.80) TBXAS1ALDH1A1GAANPC1CYP19A1
SCHEMBL3347584 0.73 TBXAS1 (0.59) TBXAS1ALDH1A1NPC1DAO
SCHEMBL9836386 0.73 TBXAS1 (0.72) TBXAS1ALDH1A1GAACYP19A1
SCHEMBL9834927 0.70 TBXAS1 (0.80) TBXAS1ALDH1A1GAANPC1CYP19A1
SCHEMBL9836067 0.70 TBXAS1 (0.50) TBXAS1ALDH1A1NPC1DAO
SCHEMBL9834596 0.69 TBXAS1 (1.00) TBXAS1ALDH1A1GAA
Hydrochloric Acid SCHEMBL9836537 0.68 TBXAS1 (0.98) TBXAS1ALDH1A1GAA
SCHEMBL9835122 0.67 TBXAS1 (0.70) TBXAS1ALDH1A1GAACYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0240107-B1 THIANAPHTHENE DERIVATIVES, THEIR PRODUCTION AND USE Sankyo Company Limited (JP) 1991-08-21 EP disclosed