Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834522 | 0.82 | ALDH1A1 (0.42) | KMT2AKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL10889852 | 0.80 | PDE3B (0.48) | KDM4EALDH1A1HSD17B10TP53MAPT | |
| SCHEMBL10892553 | 0.77 | PDE3B (0.51) | KMT2AALDH1A1TP53MAPTGAA | |
| SCHEMBL9834011 | 0.76 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10TP53MAPT | |
| SCHEMBL9267668 | 0.76 | GAA (0.70) | KDM4EALDH1A1HSD17B10TP53MAPT | |
| SCHEMBL9836605 | 0.74 | GSTP1 (0.49) | KMT2APDE3BPDE3A | |
| SCHEMBL10855137 | 0.74 | PDE3B (0.40) | KMT2AALDH1A1PDE3BPDE3A | |
| SCHEMBL10809454 | 0.73 | PDE3B (0.54) | KMT2AALDH1A1NPSR1PDE3BPDE3A | |
| SCHEMBL7327646 | 0.72 | MAPT (0.65) | KMT2AKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL12646476 | 0.72 | GAA (0.64) | KDM4EALDH1A1HSD17B10TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |