Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836476 | 0.87 | TDP1 (0.48) | TDP1PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9837594 | 0.83 | PDE3B (0.41) | ALDH1A1TDP1PDE3BPDE3APDE4A | |
| SCHEMBL9836932 | 0.83 | TSHR (0.43) | ALDH1A1L3MBTL1PDE3BPDE3APDE4A | |
| SCHEMBL9835522 | 0.82 | HPGD (0.45) | ALDH1A1L3MBTL1PDE3BPDE3APDE4A | |
| SCHEMBL9835928 | 0.82 | KMT2A (0.48) | ALDH1A1PDE3BPDE3AGAAMAPT | |
| SCHEMBL9836049 | 0.81 | MEN1 (0.50) | ALDH1A1PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9835976 | 0.81 | SMN1; SMN2 (0.47) | ALDH1A1L3MBTL1PDE3BPDE3APDE4A | |
| SCHEMBL9834628 | 0.80 | MAPT (0.43) | ALDH1A1PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10760597 | 0.78 | PDE3B (0.42) | ALDH1A1PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9836264 | 0.77 | PDE3B (0.38) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |