Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827152 | 0.93 | LMNA (0.43) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL11858775 | 0.82 | ALDH1A1 (0.45) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL9827620 | 0.79 | HPGD (0.38) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL8469458 | 0.78 | CA12 (0.50) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL3650210 | 0.76 | ALDH1A1 (0.45) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL10612173 | 0.74 | LMNA (0.53) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL9826766 | 0.74 | LMNA (0.41) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL9181456 | 0.73 | RECQL (0.52) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL10626068 | 0.73 | LMNA (0.51) | LMNAHPGDHIF1AHSD17B10GAA | |
| SCHEMBL9826955 | 0.73 | HPGD (0.40) | LMNAHPGDHIF1AHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215319-B1 | GEM-DIHALO-1,8-DIAMINO-4-AZA-OCTANES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | claimed |