SCHEMBL9836072

SCHEMBL9836072

Cc1ccc(F)c(NC(=O)Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.55
ALDH1A1 P00352 3/20 0.55
TSHR P16473 2/20 0.55
RAB9A P51151 5/20 0.54
SMN1; SMN2 Q16637 5/20 0.54
MAPT P10636 5/20 0.54
NPC1 O15118 3/20 0.54
GLA P06280 1/20 0.52
PKM P14618 1/20 0.50
KMT2A Q03164 5/20 0.47
MEN1 O00255 4/20 0.47
POLB P06746 2/20 0.46
IDH1 O75874 1/20 0.46
HPGD P15428 1/20 0.46
HTT P42858 1/20 0.45
GALK1 P51570 1/20 0.45
KCNMA1 Q12791 1/20 0.44
PDGFRB P09619 1/20 0.43
KDR P35968 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20560330 0.85 HDAC1 (0.46) LMNAALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL12811744 0.85 RAB9A (0.60) LMNAALDH1A1TSHRRAB9ASMN1; SMN2
SCHEMBL10034515 0.83 LMNA (0.56) LMNAALDH1A1TSHRRAB9ASMN1; SMN2
SCHEMBL20560242 0.81 KMT2A (0.54) LMNAALDH1A1TSHRRAB9ASMN1; SMN2
SCHEMBL1426650 0.81 RAB9A (0.57) LMNAALDH1A1TSHRRAB9ASMN1; SMN2
SCHEMBL4827923 0.81 HPGD (0.70) LMNAALDH1A1TSHRRAB9ASMN1; SMN2
SCHEMBL29373841 0.81 RAB9A (0.57) LMNAALDH1A1TSHRRAB9ASMN1; SMN2
SCHEMBL20560214 0.81 GRIK1 (0.50) ALDH1A1RAB9ASMN1; SMN2MAPTNPC1
SCHEMBL20560374 0.81 SMN1; SMN2 (0.51) LMNAALDH1A1TSHRSMN1; SMN2MAPT
SCHEMBL4010544 0.81 SMN1; SMN2 (0.66) LMNAALDH1A1TSHRRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108698982-B Fluorine atom-containing compound and use thereof 日产化学工业株式会社 2021-07-16 CN disclosed
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 EP disclosed
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 LMNA 4627/4885ALDH1A1 982/4885TSHR 668/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 LMNA 4627/4885ALDH1A1 982/4885TSHR 668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.