Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835247 | 0.81 | PGR (0.46) | PGRDRD2DRD4DRD3TP53 | |
| SCHEMBL9834604 | 0.81 | PGR (0.46) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9836114 | 0.81 | PGR (0.39) | PGR | |
| SCHEMBL9833666 | 0.81 | PGR (0.46) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9834779 | 0.78 | PGR (0.47) | PGRDRD2DRD4DRD3TP53 | |
| SCHEMBL9835010 | 0.78 | PGR (0.44) | PGRDRD2DRD4DRD3TP53 | |
| SCHEMBL9834612 | 0.77 | PGR (0.43) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9834376 | 0.75 | PGR (0.47) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9833705 | 0.75 | PGR (0.41) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9833014 | 0.74 | NQO2 (0.41) | PGRTP53MAPTIDO1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |