Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834636 | 0.84 | ALDH1A1 (0.37) | PGRALDH1A1 | |
| SCHEMBL9834779 | 0.81 | PGR (0.47) | PGRALDH1A1TP53MAPTLMNA | |
| SCHEMBL9834649 | 0.79 | ALDH1A1 (0.45) | PGRALDH1A1TP53MAPTPOLB | |
| SCHEMBL9833666 | 0.77 | PGR (0.46) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9834604 | 0.77 | PGR (0.46) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9835247 | 0.77 | PGR (0.46) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9836085 | 0.75 | PGR (0.44) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9835010 | 0.75 | PGR (0.44) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9834612 | 0.74 | PGR (0.43) | PGRTP53MAPTLMNAPOLB | |
| SCHEMBL9833215 | 0.72 | ALDH1A1 (0.41) | PGRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |