Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.32 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833830 | 0.83 | ALDH1A1 (0.37) | NQO2PGRIDO1TDO2ALDH1A1 | |
| SCHEMBL9834779 | 0.74 | PGR (0.47) | NQO2PGRIDO1ALDH1A1MAPT | |
| SCHEMBL9836085 | 0.74 | PGR (0.44) | NQO2PGRIDO1MAPTGAA | |
| SCHEMBL9834612 | 0.72 | PGR (0.43) | NQO2PGRMAPTTP53 | |
| SCHEMBL9834376 | 0.70 | PGR (0.47) | PGRIDO1TDO2ALDH1A1MAPT | |
| SCHEMBL9834460 | 0.69 | ATAD2 (0.42) | PGR | |
| SCHEMBL10568359 | 0.68 | PGR (0.39) | PGRMAPTTP53 | |
| SCHEMBL10821662 | 0.67 | PGR (0.52) | PGRIDO1MAPTGAACDYL2 | |
| SCHEMBL10373116 | 0.67 | TP53 (0.41) | PGRALDH1A1MAPTGAACDYL2 | |
| SCHEMBL10569328 | 0.67 | PGR (0.41) | NQO2PGRALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |