SCHEMBL9836192

SCHEMBL9836192

CC(C)c1ccc(NC(=O)Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.59
RAB9A P51151 9/20 0.56
SMN1; SMN2 Q16637 6/20 0.56
HPGD P15428 3/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
NPC1 O15118 7/20 0.54
LMNA P02545 3/20 0.54
TP53 P04637 3/20 0.54
NFKB1 P19838 2/20 0.54
NFKB2 Q00653 2/20 0.54
RELA Q04206 2/20 0.54
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
POLB P06746 2/20 0.53
ALDH1A1 P00352 1/20 0.53
MAPT P10636 1/20 0.53
EGFR P00533 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15105049 0.83 CNR1 (0.44) KIF11RAB9ASMN1; SMN2HPGDMEN1
SCHEMBL19707622 0.83 RAB9A (0.76) KIF11RAB9ASMN1; SMN2HPGDMEN1
SCHEMBL11154886 0.82 NPC1 (0.48) RAB9ASMN1; SMN2MEN1KMT2ANPC1
SCHEMBL104524 0.81 SMN1; SMN2 (0.61) KIF11RAB9ASMN1; SMN2HPGDMEN1
SCHEMBL2096251 0.81 KIF11 (0.61) KIF11RAB9ASMN1; SMN2HPGDMEN1
SCHEMBL1027400 0.81 KIF11 (0.61) KIF11RAB9ASMN1; SMN2HPGDMEN1
SCHEMBL4111411 0.80 MEN1 (0.67) KIF11RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL14208368 0.80 SMN1; SMN2 (0.58) KIF11RAB9ASMN1; SMN2HPGDMEN1
SCHEMBL11659467 0.80 PPARA (0.52) RAB9ASMN1; SMN2HPGDMEN1KMT2A
SCHEMBL16299534 0.79 KIF11 (0.59) KIF11RAB9ASMN1; SMN2HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008058995-A2 USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT (DE) 2008-05-22 WO disclosed
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed