SCHEMBL9836348

SCHEMBL9836348

C=C(C)C(OC(=O)Nc1cc(OC(C)C)c(Cl)cc1F)C(=O)OCC(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.37
DHODH Q02127 8/20 0.36
GAA P10253 2/20 0.36
MAPK1 P28482 1/20 0.36
TSHR P16473 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
LMNA P02545 4/20 0.34
MAPT P10636 4/20 0.34
NPSR1 Q6W5P4 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
ALDH1A1 P00352 1/20 0.32
P2RX3 P56373 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9836744 0.91 GAA (0.44) RORCGAAMAPK1TSHRL3MBTL1
SCHEMBL9835444 0.90 RORC (0.39) RORCDHODHGAAMAPK1TSHR
SCHEMBL9835551 0.89 DHODH (0.38) RORCDHODHGAAMAPK1TSHR
SCHEMBL27519213 0.87 LMNA (0.37) RORCDHODHGAAMAPK1TSHR
SCHEMBL27315901 0.86 LMNA (0.36) RORCDHODHGAAMAPK1TSHR
SCHEMBL27322093 0.85 DHODH (0.33) RORCDHODHGAAMAPK1LMNA
SCHEMBL9836856 0.82 LMNA (0.36) RORCDHODHGAAMAPK1TSHR
SCHEMBL9837090 0.82 SMN1; SMN2 (0.46) RORCMAPK1TSHRL3MBTL1TDP1
SCHEMBL9835963 0.81 RORC (0.39) RORCDHODHGAAMAPK1TSHR
SCHEMBL9868327 0.80 ALDH1A1 (0.40) DHODHGAAMAPK1TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1059718-A The weedicide that contains the  oxazolidinedione derivatives SAGAMI CHEM RES (JP) 1992-03-25 CN disclosed
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed