Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837257 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9837349 | 0.82 | IKBKB (0.49) | ALDH1A1HPGDGAAMEN1KMT2A | |
| SCHEMBL9837365 | 0.82 | BAZ2B (0.53) | ALDH1A1MAPTHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL9835705 | 0.80 | BAZ2B (0.54) | ALDH1A1MAPTHPGDHSD17B10GAA | |
| SCHEMBL6479967 | 0.79 | BAZ2B (0.47) | ALDH1A1MAPTHPGDHSD17B10GAA | |
| SCHEMBL6481160 | 0.79 | BAZ2B (0.47) | ALDH1A1MAPTHPGDHSD17B10GAA | |
| SCHEMBL6050604 | 0.74 | BAZ2B (0.47) | ALDH1A1MAPTHPGDHSD17B10GAA | |
| SCHEMBL15071685 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDRAB9AGAA | |
| SCHEMBL976420 | 0.72 | ALDH1A1 (0.72) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10737753 | 0.72 | NPC1 (0.41) | ALDH1A1MAPTHPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269295-B1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4877793-A | CARDIOVASCULAR DISORDERS | THE BOOTS COMPANY, PLC (GB) | 1989-10-31 | — | — | US | disclosed |
| EP-0269295-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1988-06-01 | — | — | EP | disclosed |