Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.43 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836544 | 0.86 | TDP1 (0.51) | ALDH1A1KDM4ETTRHSD17B10 | |
| SCHEMBL30668699 | 0.86 | KDM4E (0.61) | ALDH1A1KDM4EGAAMAOAPOLB | |
| SCHEMBL9837206 | 0.85 | TDP1 (0.50) | ALDH1A1KDM4ETTRNPC1RAB9A | |
| SCHEMBL9835732 | 0.85 | TTR (0.48) | ALDH1A1KDM4EGAAMAOATTR | |
| SCHEMBL9836804 | 0.85 | MAOA (0.56) | ALDH1A1KDM4EGAAMAOAPOLB | |
| SCHEMBL9837627 | 0.85 | TTR (0.51) | ALDH1A1KDM4ETTRLMNALTB4R | |
| SCHEMBL9837024 | 0.85 | KDM4E (0.52) | ALDH1A1KDM4EGAAMAOAPOLB | |
| SCHEMBL9836783 | 0.83 | PTGDR2 (0.41) | ALDH1A1KDM4EGAAMAOATTR | |
| SCHEMBL9837103 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAPOLBTTR | |
| SCHEMBL9837107 | 0.79 | MAOA (0.50) | ALDH1A1KDM4EMAOATTRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |
| EP-0175376-A2 | Xanthone derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-03-26 | — | — | EP | disclosed |