Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836544 | 0.92 | TDP1 (0.51) | TDP1TTRMAPTTSHRPTGDR2 | |
| SCHEMBL9837083 | 0.85 | ALDH1A1 (0.54) | TTRALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL9835732 | 0.79 | TTR (0.48) | TDP1TTRPTGDR2ALDH1A1KMT2A | |
| SCHEMBL9837627 | 0.78 | TTR (0.51) | TDP1TTRMAPTTSHRPTGDR2 | |
| SCHEMBL9836783 | 0.77 | PTGDR2 (0.41) | TDP1TTRPTGDR2ALDH1A1KDM4E | |
| SCHEMBL9834846 | 0.75 | AHR (0.54) | TTRMAPTMEN1KMT2AAHR | |
| SCHEMBL30668699 | 0.72 | KDM4E (0.61) | ALDH1A1NPC1RAB9AKMT2ALTB4R | |
| SCHEMBL9837024 | 0.71 | KDM4E (0.52) | TTRMAPTALDH1A1MEN1NPC1 | |
| SCHEMBL9836804 | 0.71 | MAOA (0.56) | TTRALDH1A1NPC1RAB9ALTB4R | |
| SCHEMBL11250401 | 0.71 | FFAR4 (0.58) | TDP1MAPTTSHRPTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |
| EP-0175376-A2 | Xanthone derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-03-26 | — | — | EP | disclosed |