SCHEMBL9837085

SCHEMBL9837085

NN1CCCCCCc2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 5/20 0.46
AVPR1A P37288 5/20 0.46
TSHR P16473 2/20 0.46
SIGMAR1 Q99720 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CHRM2 P08172 1/20 0.44
CHRM4 P08173 1/20 0.44
CHRM1 P11229 1/20 0.44
CHRM3 P20309 1/20 0.44
NOTUM Q6P988 1/20 0.43
OXTR P30559 2/20 0.43
MEN1 O00255 2/20 0.42
ALDH1A1 P00352 2/20 0.42
KMT2A Q03164 2/20 0.42
KEAP1 Q14145 1/20 0.42
USP2 O75604 1/20 0.42
CDK4 P11802 1/20 0.42
ALOX15 P16050 1/20 0.42
CCND1 P24385 1/20 0.42
MGLL Q99685 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1448243 1.00 AVPR2 (0.46) AVPR2AVPR1ATSHRSIGMAR1SMN1; SMN2
SCHEMBL1447375 0.98 TSHR (0.48) AVPR2AVPR1ATSHRSIGMAR1SMN1; SMN2
SCHEMBL483231 0.92 SMN1; SMN2 (0.53) TSHRSIGMAR1SMN1; SMN2NOTUMMEN1
SCHEMBL29612036 0.92 SMN1; SMN2 (0.53) TSHRSIGMAR1SMN1; SMN2NOTUMMEN1
Hydrochloric Acid SCHEMBL5428326 0.90 SMN1; SMN2 (0.52) TSHRSIGMAR1SMN1; SMN2NOTUMMEN1
SCHEMBL29625280 0.83 MEN1 (0.54) TSHRSIGMAR1SMN1; SMN2NOTUMMEN1
SCHEMBL112247 0.83 MEN1 (0.54) TSHRSIGMAR1SMN1; SMN2NOTUMMEN1
Hydrochloric Acid SCHEMBL1163794 0.81 MEN1 (0.52) TSHRSIGMAR1NOTUMMEN1ALDH1A1
Hydrochloric Acid SCHEMBL27490360 0.81 MEN1 (0.52) TSHRSIGMAR1NOTUMMEN1ALDH1A1
SCHEMBL23601610 0.76 MEN1 (0.50) AVPR2AVPR1ATSHRSIGMAR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5066649-A 8,9-annelated-1,2,3,4-tetrahydro-β-carboline derivatives DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1991-11-19 US disclosed
EP-0380155-A1 8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1990-08-01 EP disclosed
EP-0320075-A1 8,9-Annelated-beta-carbolines and 8,9-annelated-3,4-dihydro-beta-carbolines DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1989-06-14 EP disclosed