Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | OXTR | P30559 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448243 | 0.98 | AVPR2 (0.46) | TSHRAVPR2AVPR1ASIGMAR1SMN1; SMN2 | |
| SCHEMBL9837085 | 0.98 | AVPR2 (0.46) | TSHRAVPR2AVPR1ASIGMAR1SMN1; SMN2 | |
| SCHEMBL29612036 | 0.94 | SMN1; SMN2 (0.53) | TSHRSIGMAR1SMN1; SMN2NOTUMMEN1 | |
| SCHEMBL483231 | 0.94 | SMN1; SMN2 (0.53) | TSHRSIGMAR1SMN1; SMN2NOTUMMEN1 | |
| Hydrochloric Acid SCHEMBL5428326 | 0.92 | SMN1; SMN2 (0.52) | TSHRSIGMAR1SMN1; SMN2NOTUMMEN1 | |
| SCHEMBL29625280 | 0.85 | MEN1 (0.54) | TSHRSIGMAR1SMN1; SMN2NOTUMMEN1 | |
| SCHEMBL112247 | 0.85 | MEN1 (0.54) | TSHRSIGMAR1SMN1; SMN2NOTUMMEN1 | |
| Hydrochloric Acid SCHEMBL27490360 | 0.83 | MEN1 (0.52) | TSHRSIGMAR1NOTUMMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1163794 | 0.83 | MEN1 (0.52) | TSHRSIGMAR1NOTUMMEN1ALDH1A1 | |
| Propane SCHEMBL6216652 | 0.78 | ALDH1A1 (0.52) | TSHRSIGMAR1NOTUMMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473563-B1 | REACTIVE CYANINE COMPOUNDS | PROMEGA CORP (US) | 2019-06-19 | — | — | EP | disclosed |
| US-8309059-B2 | Reactive cyanine compounds | PROMEGA CORPORATION (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110053162-A1 | REACTIVE CYANINE COMPOUNDS | PROMEGA CORPORATION (US) | 2011-03-03 | — | — | US | disclosed |
| US-7238690-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-03 | — | — | US | disclosed |
| US-20060178362-A1 | Substituted heterocyle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2006-08-10 | — | — | US | disclosed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |
| US-20040209864-A1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-10-21 | — | — | US | disclosed |
| EP-1189905-B1 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-09-29 | — | — | EP | disclosed |
| US-20040127482-A1 | Administering substituted heterocycle fused gamma-carboline compounds for therapy of addictive behavior associated with 5HT2C receptor modulation | ROBICHAUD ALBERT J (US) | 2004-07-01 | — | — | US | disclosed |
| EP-0805157-B1 | INDOLE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES (JP) | 2003-06-04 | — | — | EP | disclosed |
| EP-1025087-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999021836-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-06 | — | — | WO | disclosed |
| EP-0906283-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| US-5849731-A | Indole derivatives and medical application thereof | TORAY INDUSTRIES, INC. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997048683-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |
| EP-0805157-A1 | INDOLE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1997-11-05 | — | — | EP | disclosed |
| US-5324725-A | Antiinflammatory agent, antiallergen | KALI-CHEMIE PHARMA GMBH (DE) | 1994-06-28 | — | — | US | disclosed |
| US-5223625-A | Antagonistic acitivity on 5-hydroxytryptamine receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1993-06-29 | — | — | US | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053162-A1 | REACTIVE CYANINE COMPOUNDS | IK, CRYAA, POLL | TSHR 4125/4885AVPR2 4494/4885AVPR1A 4552/4885 |
| US-20040209864-A1 | Substituted heterocycle fused gamma-carbolines | HCRTR1, HTR2C, OPRK1 | TSHR 485/4885AVPR2 424/4885AVPR1A 328/4885 |
| US-20060178362-A1 | Substituted heterocyle fused gamma-carbolines | HTR2B, HTR1B, HTR3B | TSHR 294/4885AVPR2 572/4885AVPR1A 215/4885 |
| US-20040127482-A1 | Administering substituted heterocycle fused gamma-carboline compounds for therapy of addictive behavior associated with 5HT2C receptor modulation | HTR2C, HTR2B, HTR3B | TSHR 384/4885AVPR2 366/4885AVPR1A 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.