SCHEMBL9837229

SCHEMBL9837229

CCOc1cc(NC(=O)Cl)c(F)cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
MITF O75030 1/20 0.48
THRB P10828 1/20 0.48
MAPK1 P28482 1/20 0.48
RORC P51449 1/20 0.47
ALDH1A1 P00352 4/20 0.43
DHODH Q02127 2/20 0.43
POLB P06746 3/20 0.43
LMNA P02545 4/20 0.43
KCNQ3 O43525 1/20 0.43
KCNQ2 O43526 1/20 0.43
GAA P10253 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HPGD P15428 1/20 0.42
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
CYP1A2 P05177 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9837675 0.86 KDM4E (0.51) KDM4ENPC1RAB9AMITFTHRB
SCHEMBL9836975 0.83 NPSR1 (0.55) KDM4ENPC1RAB9AALDH1A1POLB
SCHEMBL9836434 0.81 POLB (0.40) KDM4ENPC1RAB9ARORCALDH1A1
SCHEMBL27674976 0.80 PPOX (0.40) KDM4ENPC1RAB9AMITFTHRB
SCHEMBL9836594 0.79 RORC (0.47) KDM4ENPC1RAB9AMAPK1RORC
SCHEMBL27313981 0.77 KDM4E (0.38) KDM4ENPC1RAB9AMITFTHRB
SCHEMBL19088271 0.75 PPOX (0.46) KDM4ERAB9ARORCALDH1A1LMNA
SCHEMBL27350033 0.75 DHODH (0.38) KDM4ENPC1RAB9AMITFTHRB
SCHEMBL9835963 0.75 RORC (0.39) KDM4ENPC1RAB9AMITFTHRB
SCHEMBL9836639 0.74 DHODH (0.39) KDM4ENPC1RAB9AMITFTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed