SCHEMBL9837675

SCHEMBL9837675

CCOc1cc(NC(=O)Cl)c(Cl)cc1Cl

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.51
MAPK1 P28482 2/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
MITF O75030 1/20 0.51
THRB P10828 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
HPGD P15428 1/20 0.51
RORC P51449 1/20 0.50
ALDH1A1 P00352 5/20 0.47
CYP1A2 P05177 3/20 0.46
CYP2C19 P33261 3/20 0.46
MAPT P10636 5/20 0.45
RECQL P46063 1/20 0.45
LMNA P02545 3/20 0.45
L3MBTL1 Q9Y468 1/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
CYP2C9 P11712 1/20 0.43
GAA P10253 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25658780 0.87 ALDH1A1 (0.61) KDM4EMAPK1NPC1RAB9AMITF
SCHEMBL9837229 0.86 KDM4E (0.48) KDM4EMAPK1NPC1RAB9AMITF
SCHEMBL9835407 0.81 LMNA (0.61) KDM4ESMN1; SMN2HPGDALDH1A1MAPT
SCHEMBL25658469 0.79 ALDH1A1 (0.52) KDM4EMAPK1NPC1RAB9AMITF
SCHEMBL25658446 0.78 ALDH1A1 (0.62) KDM4EMAPK1NPC1RAB9AMITF
SCHEMBL9836947 0.77 GAA (0.56) KDM4EMAPK1HPGDRORCALDH1A1
SCHEMBL10891186 0.77 ALDH1A1 (0.70) KDM4EMAPK1NPC1RAB9AMITF
SCHEMBL25172615 0.76 KDM4E (0.47) KDM4EMAPK1NPC1RAB9AMITF
SCHEMBL9835812 0.74 MEN1 (0.41) HPGDALDH1A1MAPTLMNAL3MBTL1
SCHEMBL27309659 0.74 RORC (0.41) KDM4EMAPK1NPC1RAB9AMITF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed