Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556787 | 0.83 | TDP1 (0.54) | POLBTDP1LMNAMAP2K1KDM4E | |
| SCHEMBL30441012 | 0.82 | KDM4E (0.46) | POLBTDP1ADRA1AADRA1BLMNA | |
| SCHEMBL29550920 | 0.81 | POLB (0.60) | POLBATRTDP1LMNASMN1; SMN2 | |
| SCHEMBL2659360 | 0.81 | POLB (0.60) | POLBATRTDP1LMNASMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL28013995 | 0.81 | KDM4E (0.44) | POLBTDP1ADRA1AADRA1BLMNA | |
| Tert-Butanol SCHEMBL25377982 | 0.79 | KDM4E (0.43) | POLBTDP1ADRA1AADRA1BLMNA | |
| SCHEMBL163493 | 0.79 | POLB (0.45) | POLBATRTDP1ADRA1AADRA1B | |
| SCHEMBL2633213 | 0.79 | P2RX7 (0.56) | POLBATRTDP1ADRA1AADRA1B | |
| SCHEMBL2085783 | 0.78 | TSHR (0.56) | POLBLMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL11931402 | 0.78 | L3MBTL1 (0.49) | POLBATRTDP1LMNAMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210782-B1 | PYRIDINE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-04-17 | — | — | EP | disclosed |