Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 2/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.39 |
| ▸ | ACE | P12821 | 4/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837445 | 1.00 | ITGA4 (0.42) | ITGA4ITGB7KLK5CYP11B1CYP11B2 | |
| SCHEMBL503425 | 0.87 | GSTP1 (0.46) | KLK5CYP11B1CYP11B2ACEACE2 | |
| SCHEMBL9837838 | 0.85 | GSTP1 (0.44) | KLK5CYP11B1CYP11B2ACEACE2 | |
| SCHEMBL9837834 | 0.85 | GSTP1 (0.44) | KLK5CYP11B1CYP11B2ACEACE2 | |
| SCHEMBL8254417 | 0.84 | CYP11B1 (0.53) | KLK5CYP11B1CYP11B2ACEACE2 | |
| SCHEMBL9838711 | 0.83 | TACR1 (0.50) | ITGA4ITGB7KLK5CYP11B1CYP11B2 | |
| SCHEMBL9838717 | 0.83 | TACR1 (0.50) | ITGA4ITGB7KLK5CYP11B1CYP11B2 | |
| SCHEMBL30674909 | 0.77 | KLK5 (0.46) | ITGA4ITGB7KLK5ACE | |
| Histidine SCHEMBL18301539 | 0.76 | GSTP1 (0.37) | ITGA4ITGB7KLK5ACEACE2 | |
| Histidine SCHEMBL18301538 | 0.76 | GSTP1 (0.37) | ITGA4ITGB7KLK5ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245637-B1 | 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| US-4816463-A | HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| US-4812462-A | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0245637-A1 | 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives and analogs having antihypertensive activity | WARNER-LAMBERT COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |